Research in my laboratory is focused on double-stranded RNA (dsRNA)-its biologic functions and the proteins that bind it to mediate these functions. Our studies are divided between two dsRNA-mediated pathways: RNA editing by adenosine deaminases that act on RNA (ADARs), and RNA interference (RNAi). For both pathways we perform in vitro studies to answer mechanistic questions, and in vivo studies in C. elegans to understand biologic function. dsRNA binding proteins (dsRBPs) bind tightly to dsRNA of any sequence, and a dsRNA substrate for one dsRBP is also a substrate for others. This suggests that different dsRNA-mediated pathways intersect and affect each other, and thus, we also study how RNA editing affects RNAi.