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2002
Fellow
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Xochitl Perez-Martinez,
Ph.D.
Departamento de Bioquimica Instituto de Fisiología Celular, UNAM
Circuito Escolar s/n.
Ciudad Universitaria
México DF 04510
Mexico
Tel: 011-52-555-622-5662
Email: xperez@ifc.unam.mx
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Country:
MEXICO
Field:
Mitochondrial
Genetics
Research Interest:
We are interested in the study
of the mechanisms that regulate the expression of the mitochondrial COX1
gene in Saccharomyces cerevisiae. This gene encodes subunit I of the cytochrome
c oxidase, which is centrally important to the enzyme. It is the largest
subunit of the complex and is an integral part of the catalytic core of
the enzyme, which is shared with subunit II. Expression of COX1 is very
complex and not completely understood. We are investigating the possibility
that the synthesis of subunit I is feedback regulated by the presence
of the assembled subunit II. In addition, we are studying the role of
the MSS51 nuclear gene product in the expression of the COX1 mRNA. This
protein has been previously implicated in some posttranscriptional step
of COX1 gene expression, probably in translation, but its mechanism of
action remains unclear.
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