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Note: This list is provided as a service to potential applicants who may wish to apply to one of these well established labs. However, applicants to the Pew Latin American Fellows Program may select a mentor/sponsoring lab at an academic institution of their choice within the United States. Please click on the research area below to read the job
listing. Research Area: Computational Biology, Gene networks and MicroRNAs Project title: microRNA regulatory networks in vertebrate development
Description of project: A postdoctoral position is available immediately to study the microRNA gene regulatory network in zebrafish as a model system. My lab combines genetics with gene expression profile and computational biology to identify the miRNA targets in vivo and understand their functions during development. Applicants require a strong background of computational biology, and perl programming, experience in molecular biology or developmental biology is preferred but not necessary. Please e-mail CV and names of three references to: Research Area: Synaptic transmission, synaptic plasticity, fusion pores, exocytosis, membrane fusion, fusion machine, synaptotagmin, SNARE, botulism, tetanus Description of project: To use modern imaging and biophysical methods to study the modes of exocytosis at nerve terminals, and to relate changes in the mode of neurotransmitter release with synaptic plasticity. Also, to study the 'mechanics' of reconstituted fusion machines, and to study bacterial the toxins that cause botulism and tetanus. A postdoctoral position is available immediately to study fusion pores that mediate the release of neurotransmitters from neurons using optical, biophysical and biochemical approaches and/or to study the structure and function of reconstituted membrane fusion machines. Applicants with a strong background in: membrane biophysics, optical imaging, sub cellular fractionation, and membrane protein biochemistry are encouraged to apply. Please forward CV and names of three references to: Phone: (608) 263-1762
Research Area: Structural Biology of Chromatin Factors and Enzymes Description of project: A postdoctoral position is available to determine the structures of eukaryotic gene regulatory complexes including histone modificatione enzymes and transcription factors bound to nucleosomes. Crystals are available for some projects, while crystallization conditions need to be determined or optimized for others. The Tan laboratory is fully equipped for biochemical, crystallization and crystallography work. Our efforts are also enhanced by techniques to reconstitute multicomponent complexes (Nature Struct. Biol., 8:695, 2001, Prot. Expr. Purif., 40:385, 2005, MCB, 25:5535, 2005) and crystallization design ideas developed during successful structural determination of the yeast TFIIA/TBP/DNA and MATalpha2/MCM1/DNA ternary complexes (Nature, 381:127, 1996; Nature, 391:660, 1998; JMB 297:947, 2000). Crystallographers and molecular biologists/biochemists who would like to learn crystallography are encouraged to apply. Prior experience with macromolecular crystallography and protein expression/purification is preferred but not essential. Please send curriculum vitae and the names of three references to:
Research Area: Molecular Neuroscience of Behavior Description of project: A postdoctoral position is available immediately to study the neural code that underlies innate behavior initiated by olfactory cues in the mouse. We have recently identified and purified a pheromone ligand that promotes aggression (Chamero et al Nature 450:899). This study revealed the existence of a second ligand which we now aim to identify. We will utilize calcium imaging, biophysical fractionation, molecular biology, mouse behavioral assays, and immunohistochemistry to purify and validate the pheromone ligand. We are skilled and able to train new postdocs in all necessary techniques; however the strongest candidates will already have expertise in one of these areas and an interest in olfactory neurobiology. Please forward CV and names of three references to:
Research Area: cell biology, genetics, imaging Description of project: A postdoctoral position is available immediately
to study the three-dimensional organization of the nuclear genome".
We are using a set of biochemical, genetic, cell biological methods to
understand the biogenesis and organization of the cell nucleus.
Research Area: theory of evolvability Description of project: A postdoctoral position is available to study evolutionary theory. The Masel group's main research interests are in evolvability, gene networks, canalization, and evolutionary capacitance, using a mixture of analytical theory, bioinformatic and simulation approaches. Funding is not tied to a specific project, but applications that do not demonstrate substantial familiarity with our work will not receive a reply. The position is renewable over multiple years, with a start date in mid-2008. Ph.D. with strong quantitative background and computational and/or modeling
experience is required. A background in evolutionary theory is preferred.
Research Area: Membrane protein crystallography Description of project: A postdoctoral position is available immediately to study the structure and mechanism of active transport (See Nature, 450: 515-521; PNAS,102:17969-17974; and Mol.Cell, 12:651-661). The lab is well-funded with access to the latest equipments for protein crystallization, cryoelectron microscopy, and other biophysical measurements. For more information please visit our website at http://chen.bio.purdue.edu. Applicants with a strong background in biochemistry and crystallography are preferred. Please forward CV and names of three references to:
Research Area: Transcription, Chromatin, Gene Regulation and Molecular Virology Description of project: A postdoctoral position is available to study mechanisms of chromatin-dependent transcription and posttranslational modification of transcription factors, cofactors and the general transcription machinery. In vitro-reconstituted chromatin transcription systems are frequently used in the lab to identify the factors and pathways leading to gene activation and repression. Current studies include functional interplays between tumor suppressor proteins, such as p53, and various DNA tumor virus-encoded oncoproteins. Several cellular chromatin adaptors, including Brd4 and SMC5/SMC6, are also studied to define their roles in mediating cellular and viral gene expression. Applicants with a strong background in protein biochemistry, molecular biology and virology are preferred. Please forward CV and names of three references to:
Research Area: Structural Biology of Dynein Description of project: A postdoctoral position is available immediately to study the 3D structure and function of the molecular motor Dynein using cryo-electron tomography, sub-tomogram averaging and classification (Nicastro et al. 2006 Science 313:944). Applicants with a strong background in: cryo-EM or with Dynein preferred. Please forward CV and names of three references to:
Research Area: Cilia and Flagella Description of project: A postdoctoral position is available immediately
to study cilia and flagella in the model organism Chlamydomonas or Tetrahymena
using molecular genetic approaches (KO, RNAi), biochemistry and imaging. Please forward CV and names of three references to: Research Area: Proteomics of Cytoskeletal Assemblies Description of project: A postdoctoral position is available immediately to study the proteomics of cytoskeletal assemblies, such as axonemes and MTOC, using biochemical approaches, mass spectrometry and imaging. Applicants with a strong background in: biochemistry and mass. spec., cytoskeleton preferred. Please forward CV and names of three references to:
Research Area: Correlative Light and Electron Microscopy Description of project: A postdoctoral position is available immediately in our newly implemented cellular visualization facility for Correlative Light and Electron Microscopy (CLEM), to collaborate with cell and neurobiologists to perform state of the art cellular imaging. Applicants with a strong background in: TEM specimen preparation, LM and TEM imaging preferred. Please forward CV and names of three references to:
Research Area: Viral Vaccine Immunology Description of project: A postdoctoral position is available immediately to study the cellular and molecular mechanisms regulating the development of long term antibody and memory B cell responses, including the roles of CD4 T cells, specific proteins of interest, and aspects of neutralizing antibody selection. The goal of the laboratory is to elucidate the immunobiology of successful vaccines and apply those principles/mechanisms to the development of future vaccines. The smallpox vaccine is the primary experimental model system used, both in mice and man, with addition viral and protein immunogen systems also utilized. Applicants with a strong background in: immunology, molecular biology,
or infectious diseases preferred.
Research Area: Phosphorylation signaling in cancer, inflammation and Alzheimer's disease Description of project: A postdoctoral position is available immediately to study phosphorylation signaling in cancer, inflammation and Alzheimer's disease (see review: Lu, K. P. and Zhou, X. Z., 2007, The prolyl isomerase Pin1: A pivotal new twist in phosphorylation signalling and disease. Nature Reviews Mol. Cell. Biol. 8: 904-916.) Applicants with a strong background in: Cell biology, neurobiology or immunity preferred. Please forward CV and names of three references to:
Research Area: Cell Motility and Actin Cytoskeleton Applicants with a strong background in Biophysics, or Material Science
or Bioengineering with some working knowledge of high resolution TEM
Research Area: Herbal medicines/dietary supplements use in the
prevention and treatment of prostate cancer
Research Area: Stem Cell and Developmental Biology Description of project: A postdoctoral position is available immediately to investigate the molecular mechanisms of stem cell differentiation. Applicants with a strong background in: Stem cell biology preferred. Please forward CV and names of three references to:
Research Area: Regulation of human transcription by non-coding RNAs Description of project: A postdoctoral position is available immediately to study the control of mRNA transcription by non-coding RNAs in human cells. Specifically, we are studying the mechanism of transcriptional repression by ncRNAs that bind directly to RNA polymerase II, including the repression of transcription by human Alu RNA in response to heat shock (Molecular Cell, 2008, 29: 499-509). We are also interested in engineering non-coding RNAs to control transcription and cell growth in model systems relevant to human disease. The experimental approaches encompass mechanistic biochemical studies in a reconstituted transcription system through genome-wide analysis of transcription and ncRNA occupancy in human cells. Applicants with a strong background in biochemistry, mammalian cell culture, or microarrays preferred. Please forward CV and names of three references to:
Research Area: Directed Evolution and Mechanistic Analysis of Fluorescent Proteins Description of project: A postdoctoral position is available immediately to study fluorescent proteins (FPs), including DsRed and its variants. One line of investigation involves using directed evolution to engineer specific structural and photophysical properties into existing FPs. This work involves creating truly monomeric FP variants, and optimizing them for brightness, spectral properties, and photostability. A complementary line of investigation focuses on the underlying chemical mechanisms that generate the FP chromophores. This work involves using a combination of crystallography, biophysical analysis, and biochemistry to dissect chromophore maturation pathways. Both approaches are integrated with cell biology experiments aimed at characterizing the behavior of FPs in living systems. This project will be jointly mentored by a cell biologist (Ben Glick) and a structural biologist (Bob Keenan), both of whom have expertise with directed evolution of FPs. Applicants with a strong background in: biochemistry, structural biology, and/or cell biological imaging preferred. Please forward CV and names of three references to:
Research Area: Chromatin and Epigenetics Description of project: Applications are invited from highly ambitious and motivated scientists for a Postdoctoral Research Fellowship position in the Department of Biochemistry and Molecular Biology at the University of Southern California's Norris Comprehensive Cancer Center in sunny Los Angeles. The overall goals of the lab are to understand the role of chromatin and epigenetics in normal development and disease progression using a diverse array of model systems and cutting-edge technologies. The focus of the lab is on histone modifications. For more information on the lab and PI, visit http://www.histonecode.com. Current available research projects include, but are not limited to: 1) Defining the epigenomic signatures of various human cells, especially stem cells, in terms of DNA methylation and histone modifications using available ultrahigh-throughput ChIP-Seq technology. 2) Implementing a novel method developed in the lab to isolate, identify and study post-translational modification-specific histone binding proteins in vivo. 3) Determining the function and biological significance of the methylation of histone H4K20 by PR-Set7 and Suv4-20 in transcription, the cell cycle, DNA replication, DNA damage/repair and genomic stability. 4) Studying the role of critical chromatin modifiers in C. elegans development and longevity. A strong foundation in biochemistry and molecular biology are required. A high level of proficiency in speaking, writing and reading English are also required. Experience in computational bioinformatics, chromatin/epigenetics techniques, mouse models, C. elegans, human ES cells or primary mammalian cell culture are desired. The candidate must have obtained a Ph.D. or M.D. degree within the last five years. Salary will be determined by candidate experience using the current NIH scale. USC offers an outstanding benefits package including medical, dental and retirement. For full consideration, please submit a cover letter that includes a brief statement of your future research and career goals, your detailed CV, and the names and contact information of three references electronically to: Judd C. Rice, Ph.D. Completed applications will be reviewed upon receipt, and selected candidates will be contacted for a personal interview.
Research Area: Cell Cycle Checkpoints Description of project: A postdoctoral position is available immediately
to study cellular mechanisms that maintain genome integrity. We have recently
completed two large-scale RNAi genetic screens along with two protein-protein
interaction screens. These screens identified approximately 20 novel proteins
that have functions in maintaining genome integrity during DNA replication.
A position is open to study these proteins with the goal of defining their
genome maintenance functions. Furthermore, we wish to test the hypothesis
that several of these proteins are important tumor suppressors that are
mutated in human cancers. Please forward CV and names of three references to: David Cortez
Research Area: Cell Migration, Infectious Diseases Description of project: We are seeking a postdoctoral fellow to join an exciting interdisciplinary initiative to define the molecular machinery that drive cell migration (and used / hijacked by pathogens during infection). Work at the Hanein lab will focus on resolving the structure of these cellular assemblies through a novel use of correlative live-cell fluorescence imaging and electron tomography. Bioinformatic tools will be used to combine information derived by X-ray crystallography, and NMR, with the information generated electron microscopy imaging, to ultimately provide atomic resolutions models of these macromolecular machines. The Burnham Institute for Medical Research (www.burnham.org) forms part of a vibrant scientific community situated next to the Pacific Ocean, including the Scripps and Salk institutes, and UCSD. Applicants should hold some experience in experimental and/or computation structural biology. Please forward CV and names of three references to:
Research Area: Function and Assembly of the Vertebrate Nuclear
Pore Applicants with a strong background in Molecular and Cellular Biology
preferred. Phone: 858-534-3398
Research Area: Immunology Description of project: A postdoctoral position is available immediately to study the sensitivity of T-cells related to cancer. The goal of this project is to elucidate the basic mechanisms that lead to suboptimal T cell responses against tumor (self) antigens using novel imaging and biophysical techniques (Krogsgaard, Mol Cell, 2003; Krogsgaard et al., Nature, 2005; Krogsgaard and Davis, NI, 2005). Applicants with a strong background in: immunology, molecular biology, biophysics, bioengineering or related fields preferred. Please forward CV and names of three references to:
Research Area: Pain Circuitry Development Description of project: A postdoctoral position is available immediately
to study the development of the pain sensory circuitry, with the long-term
goal of identifying new targets for pain treatment. Our approach was to
systematically identify transcription factor (TF) genes expressed in developing
pain sensory neurons, followed by performing genetic analysis to determine
their functions. The human and mouse genomes encode about 1500 TF genes.
From 2002-2004, we had used in situ hybridization to compile a genome-scale
map of TFs expressed in the developing mouse nervous system (Science 2004;
306(5705): 2255-7). Subsequent genetic studies have led to identification
of two master regulators, Runx1 and Tlx3. Runx1 is required for the expression
of many ion channels and receptors in peripheral nociceptors, and is required
for thermal and neuropathic pain (Neuron, 49, 365-77). Tlx3 operates in
spinal pain relay nociceptors, and is required for specification of a
cohort of glutamate and peptide transmitters (Nature Neuroscience 7: 510-7;
Journal of Neuroscience 28:4037-46). Mice lacking Tlx3 also exhibit pain
deficits. The new postdoc will continue to work on how these and other
transcriptional regulators to control nociceptor cell diversity generation
and specific pain circuit assembly. Please forward CV and names of three references to:
Research Area: Normal and leukemogenic Notch signaling Description of project: Two postdoctoral positions are available immediately in the Blacklow laboratory in the Department of Pathology at Brigham and Women's Hospital to develop inhibitors targeting the Notch pathway in T-cell acute lymphocytic leukemia. Successful candidates will join a multidisciplinary team investigating T-ALL pathogenesis and inhibition using structural, biochemical, cell culture, and in vivo approaches. Applicants with a strong background in: structural and molecular biology, biochemistry, and/or cell and tissue culture are preferred. Please forward CV and names of three references to:
Research Area: Cancer Biology Applicants with a strong background in Cell or Developmental Biology preferred. Please forward CV and names of three references to: Phone: 212 734 0567 x2320
Research Areas: Rho GTPases, Wound Healing, & Transcriptional Repression Description of Project: Our lab uses developmental, genetic, cellular,
molecular, and biochemical approaches to look at different regulatory
mechanisms and pathways required for proper Drosophila embryonic development.
A postdoctoral position is available to join our research team. Our current
efforts are divided between three areas of study. **For additional information, please see our lab web site: http://www.fhcrc.org/science/labs/parkhurst/ Please forward CV and the names of three references (with contact
information) to: Tel: (206) 667-6466
Research Area: Structural virology Description of project: A postdoctoral position is available immediately to study the structural mechanisms of how herpesviruses enter cells. We use a combination of x-ray crystallography, biochemistry, and functional assays to study the entry machinery of herpesviruses. Current available projects focus on the structure of various components of the viral entry machinery and how these proteins interact. The laboratory is fully equipped for all aspects of molecular biology and biochemistry and has access to X-ray crystallography facilities and the biophysical and imaging resources at Tufts University. Applicants with a strong background in biochemistry and crystallography
are preferred. Applicants should have a Ph.D. with 0-2 years postdoctoral
research experience.
Research Area: Stem Cells Description of project: A postdoctoral position is available immediately to study the biology of adult stem cells in Drosophila. Applicants with a strong background in: Developmental Genetics preferred. Please forward CV and names of three references to: Craig Micchelli Phone: 314.362.7036
Research Area: Neurobiology and Stem Cell Biology Description of project: A postdoctoral position is available immediately to study the role of irreversible genetic and epigenetic changes in neuronal differentiation and disease. We aim to use new stem cell technologies such as cloning by nuclear transfer and viral induced pluripotency protocols to induce neurons to become pluripotent cell lines. These studies will enable us to dissect the steps involved in neuronal differentiation and cell cycle exit, and to perform whole genome analyses on individual neurons, which has not previously been possible. We ultimately wish to apply our new methods to neurons that have been affected by various neurological diseases including inherited developmental defects and late onset neurodegenerative disorders such as Parkinson’s and Alzheimer’s disease. Applicants with a strong background in: Molecular biology, cell biology, developmental biology, molecular or cellular neurobiology are preferred. We are also interested in applicants with clinical expertise in human neurological diseases or mouse models of these diseases. Please forward CV and names of three references to: Phone: 858-784-9466
Research Area: Molecular Neurobiology Description of project: A postdoctoral position is available immediately to study the formation and function of specific neural circuits in the brain, using the mouse olfactory system as a model. We take advantage of the unique organization and genetic tractability of the mouse olfactory system to label specific neural circuits in gene targeted mice, to manipulate them with genetically encoded neuronal activators or inhibitors, and to identify specific genes that may be involved in building circuits during development or in remodeling them in response to environmental stimuli. Projects in the lab include developing new genetic technologies to label and identify neurons that respond to specific odors, to understand how attractive and repulsive odors are differentially represented in the brain, and to identify genes responsible for linking sensory neurons to the cortical sites of odor perception. Applicants with a strong background in: Molecular biology, cell biology, developmental biology, virology, molecular or cellular neurobiology are preferred, though any strong applicant with experience in biomedical research or chemistry will be considered. Please forward CV and names of three references to: Phone: 858-784-9466 |
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